Engineering News -- ScienceDaily

A route for avoiding defects during additive manufacturing (Fri, 27 Nov 2020)
Research reveals how pores form during metals additive manufacturing and become defects trapped in solidifying metal. The practical value of this research is that it can inform industry on how to predict and improve 3D printing processes.
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CRISPRi screens reveal sources of metabolic robustness in E. coli (Tue, 24 Nov 2020)
Metabolic robustness, the ability of a metabolic system to buffer changes in its environment, is not always a welcome feature for microbiologists: it interferes with metabolic engineering or prevents that antibiotics kill bacteria. Therefore it is important to understand the mechanisms that enable metabolic robustness. A massively parallel CRISPRi screen demonstrated that E. colimetabolism is very robust against knockdowns of enzymes, and multi-omics data revealed the mechanisms behind it. In the future, the researchers want to apply this knowledge to build better models of metabolism, which enable rational-design of industrial microbes.
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